FOR1086     K2P-channels - from Molecule to Physiology and Pathophysiology

Publications

2015

  1. Budde T, Daut J, Kurtz A & Pape HC (2015). Two-pore-domain potassium channels: regulators of many cellular functions. Pflügers Arch. 467(5):865-866.
  2. Renigunta V, Schlichthörl G & Daut J (2015). Much more than a leak: structure and function of K2P-channels. Pflügers Arch. 467(5):867-894.
  3. Bista P, Cerina M, Ehling P, Leist M, Pape HC, Meuth SG & Budde T (2015). The role of two-pore-domain background K+ (K2P) channels in the thalamus. Pflüers Arch. 467(5):895-905.
  4. Ehling P, Cerina M, Budde T, Meuth SG & Bittner S (2015). The CNS under pathophysiologic attack--examining the role of K2P channels. Pflügers Arch. 467(5):959-972.
  5. Göb E, Bittner S, Bobak N, Kraft P, Göbel K, Langhauser F, Homola GA, Brede M, Budde T, Meuth SG & Kleinschnitz C (2015). The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration. Pflügers Arch. 467(5):973-987.
  6. Bandulik S, Tauber P, Lalli E, Barhanin J & Warth R (2015). Two-pore domain potassium channels in the adrenal cortex. Pflügers Arch. 467(5):1027-1042.
  7. Decher N, Kiper AK, Rolfes C, Schulze-Bahr E & Rinné S (2015). The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias. Pflügers Arch. 467(5):1055-1067.
  8. Bodnár M, Schlichthörl G & Daut J (2015).The potassium current carried by TREK-1 channels in rat cardiac ventricular muscle. Pflügers Arch. 467(5):1069-1079.
  9. Kilisch M, Lytovchenko O, Schwappach B, Renigunta V & Daut J (2015). The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflügers Arch. 467(5):1105-1120.
  10. Cerina M, Szkudlarek HJ, Coulon P, Meuth P, Kanyshkova T, Nguyen XV, Göbel K, Seidenbecher T, Meuth SG, Pape HC, Budde T (2015). Thalamic Kv7 channels: pharmacological properties and activity control during noxious signal processing. Br J Pharmacol. 172:3126-40.
  11. Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HC, Oliver D, Meuth SG, Budde T (2015). Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol. 593(1):127-44.
  12. Rinné S, Kiper AK, Schlichthörl G, Dittmann S, Netter MF, Limberg SH, Silbernagel N, Zuzarte M, Moosdorf R, Wulf H, Schulze-Bahr E, Rolfes C, Decher N (2015). TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes. J Mol Cell Cardiol. 81C:71-80.

2014

  1. Renigunta V, Zou X, Kling S, Schlichthörl G & Daut J (2014). Breaking the silence: Functional expression of the two-pore-domain potassium channel THIK-2. European Journal of Physiology 466, 1735-1745.
  2. Rinné S, Renigunta V, Schlichthörl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J & Preisig-Müller R (2014). A splice variant of the two-pore-domain potassium channel TREK-1 withn only one pore domain reduces the surface expression of full-length TREK-1 channels. European Journal of Physiology 466, 1559-1570.
  3. Renigunta V, Fischer T, Zuzarte M, Kling S, Zou X, Siebert K, Limberg MM, Rinné S, Decher N, Schlichthörl G & Daut J (2014). Co-operative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1. Molecular Biology of the Cell 25, 1877-1891.
  4. Ehling P, Cerina M, Budde T, Meuth SG, Bittner S (2014). The CNS under pathophysiologic attack-examining the role of K2P channels. Pflugers Arch. 2014 Dec 9. [Epub ahead of print]
  5. Bista P, Cerina M, Ehling P, Leist M, Pape HC, Meuth SG, Budde T (2014). The role of two-pore-domain background K+ (K 2P) channels in the thalamus. Pflugers Arch. 2014 Oct 28. [Epub ahead of print]
  6. Göb E, Bittner S, Bobak N, Kraft P, Göbel K, Langhauser F, Homola GA, Brede M, Budde T, Meuth SG, Kleinschnitz C (2014). The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration. Pflugers Arch. 2014 Oct 15. [Epub ahead of print]
  7. Wilke BU, Lindner M, Greifenberg L, Albus A, Kronimus Y, Bünemann M, Leitner MG, Oliver D (2014). Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.Nat Commun.5:5540.
  8. Bandulik SWarth R (2014). Two-pore domain potassium channels in the adrenal cortex. Pflugers Arch. 2014 Oct 23. [Epub ahead of print]
  9. Kiper AK, Rinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W, Decher N (2014). Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Pflugers Arch. 2014 Dec 17. [Epub ahead of print]
  10. Decher N, Kiper AK, Rolfes C, Schulze-Bahr E, Rinné S (2014). The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias. Pflugers Arch. 2014 Nov 19. [Epub ahead of print]

2013

  1. Anders C*, Higuchi Y*, Koschinsky K*, Bartel M, Schumacher B, Thiel P, Nitta H, Preisig-Müller R, Schlichthörl G, Renigunta V, Ohkanda J, Daut J+, Kato N+ & Ottmann C+ (2013). A semi-synthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chemistry & Biology 20, 583-593. *contributed equally; +corresponding author.
  2. Schiekel J, Lindner M, Wemhöner K, Renigunta V, Schlichthörl G, Decher N, Oliver D & Daut J (2013). Inhibition oft he potassium channel TASK-1 in rat cardiac muscle is mediated by phospholipase C. Cardiovascular Research 97, 97-105.
  3. Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG (2013). Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med. 19(9):1161-5.
  4. Ehling P, Bittner S, Bobak N, Schwarz T, Wiendl H, Budde T, Kleinschnitz C, Meuth SG (2013). Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9). Exp Transl Stroke Med. 5(1):3.
  5. Andronic J, Bobak N, Bittner S, Ehling P, Kleinschnitz C, Herrmann AM, Zimmermann H, Sauer M, Wiendl H, Budde T, Meuth SG, Sukhorukov VL (2013). Identification of two-pore domain potassium channels as potent modulators of osmotic volume regulation in human T lymphocytes. Biochim Biophys Acta. 1828(2):699-707.

2012

  1. Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F (2012) TWIK1, a unique background channel with variable ion selectivity. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5499-504.
  2. Bista P, Meuth SG, Kanyshkova T, Cerina M, Pawlowski M, Ehling P, Landgraf P, Borsotto M, Heurteaux C, Pape H-C, Baukrowitz T, Budde T (2012) Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons. Pflügers Arch. 463(1):89-102.
  3. Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Dang Cong L, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J. (2012) Task3 Potassium Channel Gene Invalidation Causes Low Renin and Salt-Sensitive Arterial Hypertension. Endocrinology. 2012 Aug 9. [Epub ahead of print]
  4. Bittner S, Bauer MA, Ehling P, Bobak N, Breuer J, Herrmann AM, Golfels M, Wiendl H, Buddde T, Meuth SG (2012). The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis. Exp Neurol.238(2):149-55.
  5. Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ (2012). State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin). 6(6):473-8.

2011

  1. Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J,> Sachse FB, Maier SK (2011) Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cell Physiol Biochem 28(1):77-86.
  2. Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB, Decher N (2011) TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes. Cell Physiol Biochem 28(4):613-24.
  3. Lindner M, Leitner MG, Halaszovich CR, Hammond GR, Oliver D (2011) Probing the regulation of TASK potassium channels by PI4,5P2 with switchable phosphoinositide phosphatases. J Physiol 589(Pt 13):3149-62.
  4. Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T (2011) The pore structure and gating mechanism of K2P channels. EMBO J 30(17):3607-19.
  5. Göbel K, Bittner S, Ruck T, Budde T, Wischmeyer E, Döring F, Wiendl H, Meuth SG (2011) Active immunization with proteolipid protein (190-209) induces ascending paralysing experimental autoimmune encephalomyelitis in C3H/HeJ mice. J Immunol Meth 31;367(1-2):27-32. *equal contribution
  6. Bittner S, Bobak N, Feuchtenberger M, Herrmann AM, Göbel K, Kinne RW, Hansen AJ, Budde T, Kleinschnitz C, Frey O, Tony H-P, Wiendl H, Meuth SG (2011) Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients. Arthritis Res & Ther 13: R21.
  7. Streit AK, Netter MF, Kempf F, Walecki M, Rinne S, Bollepalli M-K, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom M, Stansfeld PJ, Decher N (2011) A specific two-pore-domain potassium channel blocker defines the structure of the task-1 open pore. J Biol Chem 286(16):13977-84.
  8. Ehling P, Bittner S, Budde T, Wiendl H, Meuth SG (2011) Ion channels in autoimmune neurodegeneration. FEBS Lett 585(23):3836-42.
  9. Bobak N, Bittner S, Andronic J, Hartmann S, Mühlpfordt F, Schneider-Hohendorf T, Wolf K, Schmelter C, Göbel K, Meuth P, Zimmermann H, Döhring F, Wischmeyer E, Budde T, Wiendl H, Meuth SG*, Sukhorukov VL* (2011) Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels. BBA Biomembranes 1808(8):2036-44. *equal contribution
  10. Smith AJ, Daut J & Schwappach B (2011). Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport. Physiology 26, 181-191.

2010

  1. Bittner S, Budde T, Wiendl H, Meuth SG (2010) From the background to the spotlight: TASK channels in pathological conditions. Brain Pathology 20(6):999-1009
  2. Ehling P*, Bittner S*, Bobak N, Schwarz T, Wiendl H, Budde T, Kleinschnitz C, Meuth SG (2010) Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9). Experimental & Translational Stroke Medicine 20;2(1):14. *equal contribution
  3. Decher N*, Streit AK*, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Pollanco R, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T, Daut J (2010) RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J 7;29(13):2101-13. *equal contribution
  4. Bittner S, Bobak N, Herrmann AM, Göbel K, Meuth P, Höhn KG, Stenner M-P, Budde T, Wiendl H*, Meuth SG* (2010) The potassium channel K2P5.1 (TASK2) as a new target for multiple sclerosis. Annals of Neurol 68: 58-69. *equal contribution
  5. Gestreau C, Heitzmann D, Thomas J, Dubreuil V, Bandulik S, Reichold M, Bendahhou S, Pierson P, Sterner C, Peyronnet-Roux J, Benfriha C, Tegtmeier I, Ehnes H, Georgieff M, Lesage F, Brunet JF, Goridis C, Warth R, Barhanin J (2010) TASK2 potassium channels set central respiratory CO2 and O2 sensitivity. Proc Natl Acad Sci USA 2;107(5):2325-30.
  6. Bandulik S, Penton D, Barhanin J, Warth R (2010) TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation. Horm Metab Res. 42(6):450-7.

2009

  1. Bittner S*, Meuth SG*, Göbel K, Melzer N, Simon OJ, Weishaupt A, Budde T, Bayliss DA, Bendszus M, Wiendl H (2009) TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the CNS. Brain 132:2501-16. *equal contribution
  2. Meuth SG, Kleinschnitz C, Broicher T, Austinat M, Brauninger S, Bittner S, Fischer S, Bayliss DA, Budde T, Stoll G, Wiendl H (2009) The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice. Neurobiology of Disease 33:1-11.

2008

  1. Meuth SG*, Kanyshkova T*, Melzer N*, Bittner S, Kieseier BC, Budde T*, Wiendl H* (2008) Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation. Neurosci. Lett. 446: 133-138. *equal contribution